Download e-book for kindle: Advances in Virus Research, Volume 88 by Karl Maramorosch, Frederick A. Murphy

By Karl Maramorosch, Frederick A. Murphy

ISBN-10: 0128000988

ISBN-13: 9780128000984

The first assessment sequence in virology and released on account that 1953, Advances in Virus Research covers a various variety of in-depth reports, delivering a invaluable evaluate of the sector.

  • Contributions from best authorities
  • Comprehensive experiences for basic and expert use
  • First and longest-running assessment sequence in virology

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Human proteins related to cell cycle/centrosome, the complement and coagulation cascade, cytoskeleton, and the Golgi apparatus were enriched among the DENV interaction partners. Comparison with host interaction partners reported in other studies revealed that over 40% of the host proteins identified in this study are implicated in the replication cycle of at least one other virus. The strongest overlap was found with proteins linked to HCV infection, an expected result given the evolutionary relation of these viruses and the similarities in their replication cycles.

2003). Thus, DC-SIGN acts as a DENV attachment factor, which might facilitate the interaction of virus particles with a cellular receptor responsible for internalization. , 2006). , 2005). , 2011). Two independent studies of patient cohorts from Thailand and Taiwan show a strong association with genotypes 42 Eliana G. Acosta et al. , 2011). , 2005). , 2005). Although the participation of DC-SIGN as an essential host factor for DENV entry during in vivo infection still requires further investigation, these studies clearly support a role for DC-SIGN as a fundamental host determinant of viral pathogenesis.

2006). Thus, it remains to be investigated whether these GSLs are specific DENV binding factors required for entry and to which virus protein/signature they bind. , 2007). Unfortunately, at variance to JEV and WNW, the role of this integrin in DENV infection could not be deciphered. , 2007). These results 46 Eliana G. Acosta et al. suggest that avb3 integrin might play a role in DENV replication, but its role in entry, if any, is questionable. , 2012). These proteins participate in the PtdSer-dependent phagocytic removal of apoptotic cells.

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Advances in Virus Research, Volume 88 by Karl Maramorosch, Frederick A. Murphy


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