Read e-book online Advances in Immunology, Vol. 69 PDF

By Frank J. Dixon

ISBN-10: 0120224690

ISBN-13: 9780120224692

The Scripps study Institute, l. a. Jolla, CA. newest findings within the box of immunology. changed define layout.

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1997). A high copy number transgenic line was established and back-crossed onto pTa? mice, generating animals that expressed the tailless pTa protein in the absence or presence of endogenous pTa. The analysis of these mice revealed that tailless pTa chains efficiently restored aP T-cell development in pTa knockout mice: the severe blockage in the transition from CD25+CD44-”OW to CD25-CD44-’loWthymocytes was overcome, the proportion and cellularity of the DP compartment reconstituted, and the preferential expansion and maturation of thymocytes with functional TCRP rearrangements (P selection) reinstated.

The plus and minus symbols refer to in-frame and out-of-frame VP + (D)JP rearrangements, respectively;the symbol 0 indicates the absence of VP 3 (D)JP rearrangement (locus in germline configuration or DP + JP rearranged). (A) Perfect allelic exclusion. Out of nine pre-T cells that engage in VP + (D)JP rearrangements on the first allele, only three produce productive joints. The formation of a functional TCRP chain allows these cells to mature and, at the same time, prevents further VP -+ (D)JP rearrangements at the second allele.

Finally, the third pathway involves premature formation of an ap TCR due to TCRa rearrangements apparently occurring at low frequency in CD25+CD44-”””cells. This pathway is expected to be completely irrelevant in normal mice because, in the presence of pTa, formation of a functional TCRP chain alone is sufficient to induce proliferation and transition to the DP stage. The assumption that the latter two pathways do not play any significant role in normal a0 T-cell development is supported by the finding that the number of DP thyniocytes is not reduced in TCRa- or TCRSdeficient mice when compared with wild-type littermates.

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Advances in Immunology, Vol. 69 by Frank J. Dixon


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