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2006). , 2006). , 2007). , 2013). , demonstrated that the increase of divergent angle in the suspended nanofibers increases the shape index of the C2C12 mouse myoblasts while maintaining the cell area constant as cell–fiber adhesion points directly affect the focal adhesion arrangement. The change in the cellular geometry further alters the shape of the nucleus, thereby affecting the gene expression and functional protein synthesis (Wang and Nain, 2014). , 2002). , 2012). , 2004). 2 Illustrating the influence of scaffold topography on cell shape.

Biomaterials. 29: 561–572. , Niamat, R. , Kmiec, E. B. 2012. Proliferation of genetically modified human cells on electrospun nanofiber scaffolds. Mol Ther Nucleic Acids. 1: e59. Boyan, B. , Lohmann, C. , Cochran, D. , Schwartz, Z. 2003. Osteoblasts generate an osteogenic microenvironment when grown on surfaces with rough microtopographies. Eur Cell Mater. 6: 22–27. Cantara, S. , Soscia, D. , Larsen, M. 2012. Selective functionalization of nanofiber scaffolds to regulate salivary gland epithelial cell proliferation and polarity.

60: 184–198. L. 2001. Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: Synthetic ECM analogs for tissue engineering. Biomaterials. 22: 3045–3051. , Ramakrishna, S. 2005. Development of nanocomposites for bone grafting. Compos Sci Technol. 65: 2385–2406. S. 1999. Handbook of Nanostructured Materials and Nanotechnology. Vol. 3. Cambridge: Academic Press. M. 1991. Cellular engineering. Ann Biomed Eng. 19: 529–545. A. 2006. Methods for fabrication of nanoscale topography for tissue engineering scaffolds.

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A 10-point circle is associated with any general point of the ellipse. New properties of Fagnanos point by Ternullo M.


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